TPX2 and neoplasm: Moreover, in nude mice, subcutaneous tumour tissues formed by TPX2 knockdown HCC cells was able to increase blood levels (plasma concentration) after sorafenib oral administration at a series of time points (2nd, 8th, 20th, 40th h), whereas in nude mice, intrahepatic tumour tissue formed by TPX2 knockdown HCC cells was not able to affect blood levels after sorafenib oral administration at a series of time points (2nd, 8th, 20th, 40th h) (Supplemental Tables 1, 2).