As shown in Fig. 2, treatment with rifampicin, a typical agonist of PXR, induced the activation of the luciferase reporters (Fig. 2A), XREM-Luc, PXRE-Luc, DR3-Luc, and ER6-Luc (Fig. 2B–M) and in HCC cells (the MHCC97-L, MHCC97-H or HepG2 cells). The gene discussed is TNFRSF25; the disease is hepatocellular carcinoma.