TNC and glioblastoma: Quantification of CX43 by IHC and TNC by western blot revealed a significant downregulation of these proteins in p16-3MR+GCV GBMs compared with WT+GCV GBMs, strengthening Gja1 and Tnc as NRF2 target genes in GBM (Fig. 5k and l, Supplementary Fig. 5g).