TNC and neoplasm: Indeed, the enrichment of the senescence score predicts a worse survival in patients with GBM and multiple genes in the signature encode for proteins whose activities are associated with tumor aggressiveness and/or worse patient prognosis (CD15163; EMP364; IGFBP265; LGALS166; TMSB4X67; TNC/SDC462; SPARC68; TIMP169).