NRF2 is hyperactivated preferentially in the MES-GBM subtype58 however, NRF2/NFE2L2 and genes regulating its activity (KEAP1, SQSTM1, CUL3, RBX1, SKP1, CUL1, BTRC, SYVN1) are rarely altered in GBMs (see cbioportal.org). The gene discussed is SYVN1; the disease is glioblastoma.