CTSD and cancer: The encoded proteins were associated with diverse cellular processes compatible with cellular senescence, such as cell cycle arrest (Cdkn1a, Cdkn2a, Cdkn2b), lysosomal function (Ctsb, Ctsd, Ctsl, Ctsz, Lamp1, Lamp2), cellular growth (Igfbp2, Igfbp3), extracellular matrix interaction (Sparc, Tnc, Sdc4, Lgals1, Timp1, Mt1), cytoskeleton interaction (Pdlim4, S100a11, Tmsb4x, Sep11) and cancer (Tm4sf1, Ociad2, Emp3) (Fig. 7c).