CDKN2A and glioblastoma: To unveil the identity of senescent cells expressing p16Ink4a and targeted by the p16-3MR transgene with GCV17, we performed droplet-based single cell RNAseq (scRNAseq) on FACs sorted cells from WT and p16-3MR GBM cells collected 7 days after the last GCV injection, hereafter named early timepoint (Fig. 3a and b; Supplementary Data 1).