CDKN2A and glioblastoma: Remarkably, the median survival of GBM-bearing mice harboring p16-3MR that were treated with GCV (p16-3MR+GCV) increased significantly compared with WT mice treated with GCV (WT+GCV) or p16-3MR mice treated with vehicle (p16-3MR+vhc) (Fig. 2a–c).