The subsequent neuropathological hallmarks of sporadic AD and DS patients with AD are nearly identical, differing mainly in age of onset, with nearly all DS individuals showing Aβ plaques and neurofibrillary tangles of tau by age 40; additionally, DS males develop AD pathology at a younger age than females [1] but females experience a higher risk of death from AD than males [2]. The gene discussed is MAPT; the disease is Alzheimer disease.