AQP5 and invasive carcinoma: For example, an initial report by Jung et al. [22] has, based on 20 samples, demonstrated that AQP5 expression was significantly higher among invasive carcinoma with lymph node (LN) metastasis to those without LN metastasis, while in our analysis, one of the key findings was the observation that tumor grade was positively correlated with high level of AQP5 expression.