In summary, the similarity of our report to 3 prior reports [21–23] overall suggests that AQP5 expression carries a poor prognostic implication while some of the clinicopathological relationship between AQP5 expression with other key clinicopathological features like relationship between AQP5 expression and ER/PRE/HER and tumor grade seems to be different. The gene discussed is AQP5; the disease is neoplasm.