Of the 4 patients who underwent surgical intervention, those with 2+ and 3+ tissue CEACAM5 expression had excellent tumor fluorescence, with a mean (SD) tumor to background ratio (TBR) of 3.11 (0.45) (Figure 1 and Figure 2; eFigures 1 and 2 in Supplement 2). The gene discussed is CEACAM5; the disease is neoplasm.