The area of fluorescence in patient 8 was lower than the lesion size, but on inspection, the tumor had a significant area of necrosis (>80%); however, the viable areas demonstrated fluorescence with a strong association with areas of TTF-1 and CEACAM5 and a lack of CK 5/6 and p63 staining, indicating adenocarcinoma spectrum lesions. This evidence concerns the gene KRT5 and adenocarcinoma.