Besides, deregulation of renin-angiotensin system (RAS) due to downregulation of ACE2 increases circulating level of angiotensin II (AngII) with subsequent development and propagation of endothelial dysfunction (Al-Kuraishy et al. 2020b, Al-Kuraishy, Al-Niemi, et al. 2020; Al-Kuraishy, Al-Gareeb, Alzahrani, Alexiou, et al. 2021). This evidence concerns the gene AGT and endothelial dysfunction.