In other mouse models of PD (Parkin-, PINK1-, or VPS13C-deficient mice) mitochondrial damage and mtDNA activate cGAS–STING–IFN signaling and contribute to loss of dopaminergic neurons (Sliter et al., 2018; Hancock-Cerutti et al., 2022). The gene discussed is CGAS; the disease is Parkinson disease.