In fact, several genetic mutations in genes attributed to FTD, including C9orf72, GRN, MAPT, TARDBP, TMEM106B, VCP, CTSF, and SQSTM1 among others, encode lysosomal proteins that affect lysosomal acidification and enzymatic activity (Root et al., 2021). This evidence concerns the gene C9orf72 and frontotemporal dementia.