Studies within the last 5 yr have associated STING signaling with a wide range of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), PD, as well as several monogenic diseases such as NGLY1 deficiency (Yang et al., 2018) and NPC disease (Chu et al., 2021). This evidence concerns the gene STING1 and neurodegenerative disease.