ANGPT2 and infection: It is demonstrated that upregulation of infections-induced inflammatory markers such as tumour necrosis factor, intracellular adhesion mediator 1 and angiopoietin 2 can induce endothelial damage in the cerebral blood vessels (Conroy et al., 2012; Storm and Craig, 2014; Cruz et al., 2016; O'Regan et al., 2016; Shabani et al., 2017; Storm et al., 2019) and maybe effective in the initiation of seizures and other status epilepticus.