However, there are certain leukemia cases, for instance, acute promyelocytic leukemia (APL) patients with mutations in PML‐RARα, NPM1, and FLT3‐ITD fusion genes, and CML patients with BCR‐ABL1 gene, show significant resistance to chemotherapeutic drugs, leading to disease progression and even death.4, 5. The gene discussed is ABL1; the disease is acute promyelocytic leukemia.