Inhibition of miR‐125a‐3p was found to partially rescue p38/MAPK phosphorylation and apoptosis by circ‐MAPK4 knockdown, suggesting circ‐MAPK4 as an important modulator in the survival and apoptosis of glioma cells by regulating miR‐125a‐3p/p38/MAPK pathway.15 This evidence concerns the gene MAPK4 and central nervous system cancer.