However, there are certain leukemia cases, for instance, acute promyelocytic leukemia (APL) patients with mutations in PML‐RARα, NPM1, and FLT3‐ITD fusion genes, and CML patients with BCR‐ABL1 gene, show significant resistance to chemotherapeutic drugs, leading to disease progression and even death.4, 5. This evidence concerns the gene NPM1 and acute promyelocytic leukemia.