Additionally, the partial correlation analysis of IL‐22+ CD4+ T cells and Treg cells in peripheral blood of patients with H. pylori infection showed that after excluding the influence of IL‐22+ CD4+ T cells, the percentages of Foxp3+ Treg cells were significantly correlated with the H. pylori colonization, and the coefficient of partial correlation was 0.361 (p < .05). This evidence concerns the gene CD4 and Helicobacter pylori infectious disease.