According to the reported cases, most patients with a systematic treatment based on multi-drug chemotherapy combining radiotherapy and surgery ultimately ended up with death.[2,6–12] Some characteristic markers of the choriocarcinoma are helpful for the accurate diagnosis, Kavanagh proposed a correlation with the upregulated levels of vascular endothelial growth factor, thought to be involved in the development of trophoblastic disease.[13]. Here, VEGFA is linked to choriocarcinoma.