At the single nucleotide polymorphism (SNP) mutation level and transcriptional level, we found that MAP4, YWHAG, KSR2, SPAG9, and CEP250 gene-related loci are different in cancer and paracancer tissues, and MAP4, YWHAG, CEP135, and CEP250 differed significantly at the transcriptional level (Fig. 7). The gene discussed is CEP250; the disease is cancer.