Genes co-expressed with YWHAG showed abundant expression in the RAS signaling pathway.[38] In pancreatic cancer, CERS6-AS1 increases YWHAG expression by sponging miR-217-5p (miR-217), leading to phosphorylation of RAF1 and activation of ERK signaling,[39] and YWHAG is also involved in the regulation of PI3K/AKT pathway.[40]. The gene discussed is AKT1; the disease is familial pancreatic carcinoma.