CD40LG and Renal insufficiency: In patients with IgG or IgA M-protein, the incidence of peripheral neuropathy is lower than in patients with the IgM M-protein.[2] MM often begins with hypercalcemia, renal failure, anemia, and bone lesions symptoms, so the patients were often referred first to the department of orthopedics or department of nephrology, besides the department of hematology.