HMGA1 and hepatocellular carcinoma: As confirmed in a previous study, the cell cycle is a critical driver and a key biological process in HCC.[38] Nucleotide excision repair, pyrimidine metabolism, spliceosome, glycan degradation, and RNA degradation have also been reported to correlate with carcinogenesis and progression in various cancers.[39–41] Genomic alterations of HMGA1 showed that AMP was the major type of HMGA1 CNV in HCC.