EGFR and lung adenocarcinoma: Gene detection is a conventional treatment strategy for advanced lung adenocarcinoma, and common mutation types include epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase mutation and C-ros oncogene 1-receptor tyrosine kinase (ROS1) fusion.[1] The common mutation types of EGFR are exon 19 deletion (19DEL) and exon 21 L858R point mutation (21L858R).[2] EGFR has tyrosine kinase activity.