We reported 2 Taiwanese families, 1 was hereditary spherocytosis affected by a heterozygous mutation with c.166A > G (p.Lys56Glu) in SLC4A1 (Band 3 protein), and the other was hereditary elliptocytosis caused by a novel heterozygous SPTA1 gene mutation, c. The gene discussed is SLC4A1; the disease is hereditary spherocytosis.