SMRP has been widely studied as biomarkers for the diagnosis and prognostic monitoring of malignant mesothelioma and ovarian cancer.[11,12] Fran et al[13] showed that the high expression of SMRP in pleural fluid is of guiding significance for the diagnosis of malignant pleural mesothelioma with negative cytology. The gene discussed is MSLN; the disease is ovarian cancer.