Chen et al found that Mesothelin binding to CA125 promotes cancer cell motility and invasion via matrix metalloproteinase-7 (MMP-7) Activation and mesothelin could enhance the expression of matrix metalloproteinase-9 (MMP-9) to enhance tumor invasion.[7,8] As in previous related studies, CA125, SMRP, MMP-7, and MMP-9 may be correlated to some extent. The gene discussed is MUC16; the disease is neoplasm.