SMRP has been widely studied as biomarkers for the diagnosis and prognostic monitoring of malignant mesothelioma and ovarian cancer.[11,12] Fran et al[13] showed that the high expression of SMRP in pleural fluid is of guiding significance for the diagnosis of malignant pleural mesothelioma with negative cytology. Here, MSLN is linked to malignant mesothelioma.