It is of interest that increasing serum levels of the related enzyme serine palmitoyltransferase 1 also appeared to be protective of early AMD in most measures (OR 0.94, IVW p-value = 2.00E−03, FDR-adjusted IVW p-value = 0.05, weighted median p-value = 0.05; significant throughout leave-one-out analysis). This evidence concerns the gene SPTLC1 and age-related macular degeneration.