To date, the use of MR approaches in the context of AMD has been limited although these methods have been successfully implemented to explore the relationship between AMD and a small number of traits including lipids, thyroid function, CRP, and complement factors (Cipriani et al., 2021; Han et al., 2021; Han et al., 2020b; Li et al., 2022; Zuber et al., 2020). This evidence concerns the gene CRP and age-related macular degeneration.