High-dose baclofen is used for idiopathic generalised dystonia but it causes serious side effects, including seizures if sudden withdrawal.10 Deep brain stimulation (DBS) has emerged as an effective treatment for SD which is refractory to medical management, the children are affected by methylmalonic acidemia and suffer acute basal ganglia lesions, while the other carries a pathogenic mutation in the GNAO1 gene. This evidence concerns the gene GNAO1 and Salla disease.