CXCR4 and vulvitis: Platelets are a good source of growth factors like platelet-derived growth factor, insulin-like growth factor, vascular endothelial growth factor, and transforming growth factor-beta.6 These growth factors inhibit NF-kB and suppress pro-inflammatory cytokines like COX-2, and chemokine receptors like CXCR4, thus reducing inflammation.6-7 In a similar case, reported improvement of plasma cell vulvitis after PRP therapy, a single case reported to date in the literature.4