TSHR and autoimmune thyroid disease: Autoimmune thyroid disease (AITDs) is one of the most prevalent organ specific autoimmune disorders.1 AITDs is marked by the production of autoantibodies; which may bind and stimulate thyroid stimulating hormone receptor resulting in Graves' disease or directed against thyroid antigens causing hypothyroidism (Hashimoto's thyroiditis).2 This occurs due to exposure of environmental adversaries upon a pre-existing genetic susceptibility.3 Recent studies have linked hypovitaminosis D with immune dysfunction and generation of autoantibodies.4,5