In the animal model, it has been shown that hypothyroidism cause defect in the expression of reelin and dab1 gene thus neuronal migration and lamination during brain development.11 Studies have found that mutation in the MCT8 (SLC16A2) gene, thyroid hormone coding gene caused severe psychomotor retardation, severe neural impairment, low serum thyroid level as well structural brain abnormalities.12,13 These associations show that there may be a relation between hypothyroidism and the causation of lissencephaly. Here, RELN is linked to lissencephaly spectrum disorders.