This interaction is critical for proper neuronal migration during foetal brain development and disruption of this interaction results in lissencephaly.7 DCX and ARX-associated lissencephaly are called X-linked lissencephaly type 1 and 2, respectively (XLIS 1-2 or LISX 1-2). This evidence concerns the gene DCX and lissencephaly type 1 due to doublecortin gene mutation.