Laboratory investigations showed lymphopenia (2700/cubic mm), haemoglobin (11.5 gm%), hypokalemia (3.2 meq/l), hypoalbuminemia (2.5 gm/ dl), increased C-reactive protein (286 mg/l), elevated Anti-nuclear antibody level (8.46), Anti-SSA (anti-Sjogren's-syndrome-related antigen A autoantibodies) antibody (+++), Anti- Ro antibody (+++), random blood sugar (130 mg/dl), liver function test was normal, serology for Human immunodeficiency virus (HIV) was negative. The gene discussed is CALR; the disease is lymphopenia.