SOD1-G93A was the first transgenic mouseline to be used for the study of ALS and displays rapidly progressive motor neuronloss and limb paralysis.20 In particular, several non-cell autonomous and neuroinflammatory mechanismshave been replicated using the SOD1 mouse model.21 However, other features of human ALS, such as occasional bulbar onset anddegeneration, are not seen in SOD1 rodents.22 While these models do not completely mirror the disease phenotype seen inhumans, they do allow for detailed mechanistic study of neurodegeneration andscreening of drug targets. Here, SOD1 is linked to amyotrophic lateral sclerosis.