APC and amyotrophic lateral sclerosis: In particular, APC administration at an early disease stage delays theonset of motor neuron degeneration and has been shown to downregulate mutantSOD1 transcription in ALS neurons and microglia.26,114 APC alsorescues motor neuron pathology, including impaired autophagosome formation andTDP-43 mislocalisation, in an iPSC model of ALS.115 This suggests that APC has protective effects on both BCNSB integrity anddirectly on neurons via its transmembrane signalling mechanism.