There was a significant between group improvement in β cell function as assessed by insulin disposition index DIo [mean (95% CI) = 0.7 mmol/L (0.03, 1.5); p = 0.04] and reduction in insulin resistance assessed as HOMA-IR [−0.4 (−0.7, −0.04; p = 0.03] as well as total serum cholesterol [−5.4 mg/dl (−10.2, −0.6); p = 0.03] in the intervention group. The gene discussed is INS; the disease is Insulin resistance.