In cardiac hypertrophy, the PI3K-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults to regulate fundamental cellular processes including protein synthesis, proliferation, and survival, via its downstream signals, such as AKT, GSK3β, mTOR, P70S6K, and eIF-4E [30–32]. The gene discussed is RPS6KB1; the disease is cardiac hypertrophy.