CXCR3 and infection: In cases of infection with Toxoplasma gondii, which is closely related to the intracellular protozoan parasite N. caninum, CXCR3 deficiency results in the loss of ability to control intestinal infection (Cohen et al., 2013), increased brain parasite burden (Umeda et al., 2021), and severe embryonic damage in a pregnant model (Nishida et al., 2021).