CXCR3 and parasitic infectious disease: Taken together, CXCR3 and its ligands promote T cell trafficking in cell-mediated immunity, making it reasonable to believe that these chemokines may have a vital role in the pathogenesis of parasitic infections in the CNS (Rosas et al., 2005; Amin et al., 2008; Oghumu et al., 2015).