IL10 and Cowden disease: A. muciniphila was reportedly absent from patients with early-onset CD (Gobert et al., 2016; Li et al., 2016), while another group found that A. muciniphila abundance was increased in CD patients (Danilova et al., 2019); One report found that oral gavage of A. muciniphila aggravates colitis for IL-10-deficient mouse, while another study did not find the same phenotype (Seregin et al., 2017; Ring et al., 2019).