TAGAP and inflammatory bowel disease: Importantly, oral feeding of reg3g recombinant protein or intraperitoneal injection of anti-p40 monoclonal antibody greatly attenuated the DSS-induced systemic disease phenotype in wild-type and TAGAP-deficient mice, which suggests that both methods may be effective for the treatment of patients with IBD, whether or not the patients who carry the IBD-susceptible TAGAP polymorphism rs212388.