CRP/ALB ratio on day 2 was associated with SAP (OR: 1.74, 95% CI: 1.32 to 2.29, P < 0.001), death (OR: 1.73, 95%CI: 1.24 to 2.41, P = 0.001), pancreatic necrosis (OR: 1.28, 95%CI: 1.08 to 1.50, P = 0.003), and organ failure (OR: 1.43, 95%CI: 1.18 to 1.73, P < 0.001) in AP patients. The gene discussed is ALB; the disease is alkaline phosphatase measurement.