Microglia-specific knockout of atg5 had no obvious PD symptoms at 10 weeks of age in mice (Qin et al., 2021); however, there is a marked PD-like impairment of motor coordination in mice as young as 3 months old due to excessive inflammasome-mediated release IL-1β and subsequent production of pro-inflammatory factor (Cheng et al., 2020), implying that the autophagy damage caused by atg5 was age-dependent. Here, ATG5 is linked to Parkinson disease.