Also, miRNAs are responsible for high expression of SRY-related high mobility group box4 (SOX4) in endometrial cancer, as well as loss of DNA mismatch repair (DNA-MMR) genes, PTEN and many other key genes that play an important role in endometrial carcinogenesis (Boren et al., 2008; Chung et al., 2009; Wang Q et al., 2020). Here, PTEN is linked to endometrial cancer.