PTCH1 and cancer: Interestingly, PTCH1 shows the highest mutation rate in 7% (127/1867; 7%) of cancers, followed by PDGFRA (89/1867; 5%), ABL1 (Figure 4) (68/1867; 4%), FOSB (56/1,678, 3%), ALDH1A1 and CCND2 (48/1,678; 2.9%), (55/1867; 2.9%).