In this study, the expression of COL3A1, COL5A1 and COL5A2 were downregulated in EC, are of the collagen family, and they interact with elements of the extracellular matrix (ECM) including matrix metalloproteinases, tyrosine kinase receptors, integrins, and signaling pathways to affect the behavior and activity of cancer cells. This evidence concerns the gene COL5A1 and cancer.