CREB1 and Alzheimer disease: Some of the genes involved in the model have been observed to be involved in AD, of which CCT2 is significantly downregulated in AD, PPP1R1B can regulate cAMP response element-binding protein (CREB) phosphorylation, and CREB dysfunction is one of the causes of AD (Cho et al., 2015) whereas NRXN1 is involved in memory recovery in rats by affecting synaptic plasticity (Zhang et al., 2021).