As for ovarian cancer, previous studies proposed that TLS coordinates the infiltration of T cells, such as the cytotoxic T cell and CXCL13-producing CD4+ T cells, and antibody-producing PCs to advance antitumor responses (Kroeger et al., 2016; Yang et al., 2021; Ukita et al., 2022). Here, CD4 is linked to ovarian cancer.