TP53 and migraine disorder: The PI3K-Akt signaling pathway is involved in the pathophysiology of migraine (Liu H.Y. et al., 2017; Liu Y.Y. et al., 2017; Liu et al., 2017a,b), and Hippo, FoxO, and p53 signaling pathways are closely related to pain (Li et al., 2013; Chen et al., 2017; Xu et al., 2021).