The PARP hyperactivation-related cell death mechanism was detected in several RP models, such as rd1 and rd10 mice (Pde6β mutation), P23H, and S334ter rats (RHO mutation), as well as in AMD model that exposed to oxidative stress (Kaur et al., 2011; Jang et al., 2017; Olivares-González et al., 2020; Sahaboglu et al., 2020). Here, PDE6B is linked to retinitis pigmentosa 1.