Since the BRAFV600E mutations differed between childhood PTC and adolescents PTC, the risk stratification should be integrated with ultrasonography, clinical symptoms, tumor size, post-surgery serum thyroglobulin level, etc. Due to the high invasiveness of childhood PTC, surgical techniques, including total thyroidectomy or thyroid lobectomy, whether they have peripheral lymph node dissection, need to be comprehensively evaluated. Here, TG is linked to neoplasm.