Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent causes of both autosomal-dominant and sporadic PD with more than 50 different missense mutations reported and at least 16 have been associated with pathogenicity (Cilia et al., 2014; Deng et al., 2018). The gene discussed is LRRK2; the disease is Parkinson disease.