The fibrillar form of α-synuclein is most commonly associated with PD as it is located within LBs and inside the neuronal cytoplasm (Spillantini et al., 1998; Volpicelli-Daley et al., 2011; Stefanis, 2012; Ghosh et al., 2017; Gómez-Benito et al., 2020). The gene discussed is SNCA; the disease is Parkinson disease.