In the context of PD, both α-synuclein and α-synucleinA53T form amyloid structures upon prolonged incubation in solution, however, α-synucleinA53T has increased aggregation kinetics (Conway et al., 2001; Stefanis, 2012; Lashuel et al., 2013). The gene discussed is SNCA; the disease is Parkinson disease.