MYC and cancer: This is a typical trait of cancer, where clonal expansion is promoted as a response to active selection (Bissel and Radisky, 2001; Laconi et al., 2008) MYC upregulation is long known to support human cancer emergence and progression (Gabay et al., 2014), and the identification of its essential function in CC has fostered a series of speculations about a role for this process in malignant growth (Baker, 2008; Moreno, 2008; Di Gregorio et al., 2016; Paglia et al., 2020).