We previously showed that the human ortholog of Drosophila lgl, namely LLGL1 or HUGL-1, is functionally conserved (Grifoni et al., 2004), and our and other studies associated its transcriptional deregulation and/or protein delocalization with several types of cancers (Grifoni et al., 2004; Schimanski et al., 2005; Grifoni et al., 2007). This evidence concerns the gene LLGL1 and cancer.