Phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), a pivotal component of the ESCRT-0 complex, restricts tumor infiltration of cytolytic CD8+ T-cells, regulating anti-tumor immunity by inducing PD-L1+ immunosuppressive exosomes (Guan et al., 2022). This evidence concerns the gene CD8A and neoplasm.