Thousands of exosomal mRNAs, such as DNA topoisomerase I (TOP1), ATP-binding cassette, sub-family B, member 5 (ABCB5) and tyrosinase-related protein 1 (TYRP1), were identified as differentially enriched in sEVs from melanoma cells compared to melanocytes and correspond to genes associated with melanoma progression and metastasis (Ryan et al., 2010; Journe et al., 2011; Soengas and Hernando, 2017). The gene discussed is TYRP1; the disease is melanoma.