In contrast, those with metastases to lymph nodes and other organs had an average Ki-67 index rate of 68.6.32 Ki-67-positive cells were more common in nodular lesions than macular lesions in nodular melanoma.31 Ki-67 expression was significantly higher in recurrent oral mucosal melanoma than in the primary.31 This evidence concerns the gene MKI67 and nodular malignant melanoma.