In a single center study and systematic review of primary hyperoxaluria type 1 gene in Chinese, p.Gly41Trp and p.Leu33Met were the first reported mutations in AGXT, while G170R, I244T and F152I, the three most common AGXT mutations mentioned in other reports, were extremely rare in Chinese population (12). Here, AGXT is linked to primary hyperoxaluria type 1.