S1PR1 and type 1 diabetes mellitus: Moreover, CYM-5442, a selective S1PR1 agonist, induces the expression of negative immune regulator receptor genes Pdcd1, Lag3, Ctla4, Tigit, and Btla to inhibit the autoimmune ability of T cells, leading to T1D prevention in the mouse Rip-LCMV T1D models (112).