Autoimmune regulator (Aire)-overexpressing DCs upregulates CD73, Lag3, and FR4 that mediate self-tolerance, and decreases CD4+IFN-γ+ autoreactive T cells in STZ-T1D mouse-derived splenocytes, which is associated with Aire-overexpressing DCs induced T1D prevention and delay (115). This evidence concerns the gene AIRE and type 1 diabetes mellitus.