In a retrospective study including 1204 individuals, followed for 10 years, divided into 4 groups: pituitary disorders (N=331), drug-induced hyperprolactinemia (N=598), hyperprolactinemia due to hypothyroidism (N=79), and idiopathic hyperprolactinemia (N=196), there was an increased risk of death in patients harboring macroadenomas, drug-induced and idiopathic hyperprolactinemia groups, although not related to PRL levels. This evidence concerns the gene PRL and hyperprolactinemia.