TSC2 and obesity due to melanocortin 4 receptor deficiency: In mouse models of obesity, overexpression of miR-222-3p was associated with increased adiposity by targeting DNA damage inducible transcript 4 (Ddit4) in adipocyte specific miR-221/222 knockout, which was associated with the suppression of the tuberous sclerosis complex 2 (TSC2)/mTOR complex 1 (mTORC1)/ribosomal protein S6 kinase (S6K) pathway (65).