We also clarified the role of Iri in increasing the cytotoxicity of NK cells against GBM cells through enhancement of the MICA/B expression; however, we were unable to find the relationship between this toxicity related to released IFN-γ and NK marker expression after co-culturing with Bev plus Iri-treated GBM cells. The gene discussed is IFNG; the disease is glioblastoma.