The ramifications for NET-induced decreases in full length E-cadherin in the human bronchial epithelia are profound and could uncover a novel role for NETs in driving epithelial-mesenchymal transition (by increasing β-catenin), facilitating invasion of pathogens (similar to sheddases) and increasing metastases in cancer (due to loss of cell-cell adhesion) (19, 23, 82, 83). Here, CDH1 is linked to cancer.