Autosomal dominant STAT3 deficiency (AD-STAT3) is a multi-system disorder characterized by severe neonatal eczema, “cold” staphylococcal abscesses, recurrent bacterial respiratory tract infections that may lead to bronchiectasis or pneumatoceles, mucocutaneous candidiasis, eosinophilia, and markedly elevated IgE. This evidence concerns the gene IGHE and Eczematoid dermatitis.