Also AKAP11, member of A-kinase anchoring proteins required for optimal antigen presentation by DCs (52) and ATG5, a key autophagy gene needed for optimal phagosome-to-lysosome fusion and subsequent antigen processing and loading on MHC molecules (53), resulted down-regulated in the largest cluster of glioma TIDCs. The gene discussed is ATG5; the disease is central nervous system cancer.