After that, the grouping analysis of RA patients showed that there was a stronger correlation between HIPK3 and CRP (r= -0.49, p= 0.00049) in patients with 2.6 ≤ DAS28-CRP ≤ 3.2, indicating that HIPK3 has a higher clinical value in predicting CRP levels in these patients (Figure 1D). Here, HIPK3 is linked to rheumatoid arthritis.