The prognostic role of low level CD3+CD4+CD69+T/CD3+CD8+CD69+T ratio in G- sepsis may be similar to that of low level CD4+T/CD8+T ratio in sepsis in previous studies, which may reflect the imbalance of T suppression/activation of adaptive immune response during pathophysiologic process in sepsis (44, 45). The gene discussed is CD8A; the disease is Sepsis.