Interestingly, both high SOFA score and low platelet count were found to be positively correlated with CD3+CD69+T (%) and CD3+CD8+CD69+ T (%) in G- bacterial sepsis, but not in G+ sepsis, while there was no significant correlation with CD3+CD4+CD69+ T (%), which indicating that CD3+ CD8+CD69+ T may be a reliable biomarker of G- sepsis. Here, CD69 is linked to bacterial infectious disease with sepsis.