In patients with G- bacterial sepsis, the Kaplan-Meier analysis revealed that CD3+CD8+CD69+T subsets accounted for ≥2.43% (median: 21 vs. 12 days; hazard ratio (HR)= 2.351 (1.214,4.553); P=0.0019) and the ratio of CD3+CD4+CD69+ T/CD3+CD8+CD69+ T accounted for ≤0.2697 (median: 22 vs. 11 days; HR=2.618 (1.349,5.018); P=0.0005), were both significantly associated with a poor ICU discharge (Figure 4B). The gene discussed is CD8A; the disease is bacterial infectious disease with sepsis.