Patients in the G- sepsis subgroup had higher serum PCT (1.89(0.83,5.01) vs. 0.45(0.22,3.04) ng/ml) and IL-6 (60.19 (25.85,189.63) vs. 32.79 (10.03,100.05) pg/ml) than those in the G+ sepsis subgroup, and patients in the G- sepsis subgroup were at a higher risk of metabolic acidosis with a lower serum CO2CP level (24.00 (21.00,27.25) vs. 27.50 (24.00,30.75) mmol/L), as well as a lower pH and more negative base excess (BE) in arterial blood gas analysis (Table 3), compared with those in the G+ sepsis subgroup. This evidence concerns the gene IL6 and metabolic acidosis.