Among patients in the bacterial sepsis group, the changes of T lymphocyte subsets between G- sepsis and G+ sepsis subgroups were detected, and it was found that patients in the G- sepsis subgroup had higher percentages of CD3+CD8+T (26.86(16.17, 32.78) vs. 15.62 (11.81, 22.17), P=0.006), CD3+CD69+ T (3.87(2.90, 6.41)vs. This evidence concerns the gene CD69 and bacterial infectious disease with sepsis.