We found that SOFA score was positive correlated with CD3+CD69+ T (%), CD3+CD4+CD69+ T (%), and CD3+CD8+CD69+ T (%), both in bacterial sepsis group(n=66) (Supplementary Figure S3A) and G- bacterial sepsis(n=46) (Supplementary Figure S3B), however, in G+ bacterial sepsis, SOFA score was positive correlated with Treg (%) and negative correlated with CD3+CD8+T (%) (Supplementary Figure S3C). The gene discussed is CD4; the disease is bacterial infectious disease with sepsis.