Our data indicated that the level of HLA-DR in CD3+CD8+T subset was remarkably elevated in G- sepsis (versus G+ sepsis), whereas there was no significant difference in expression levels of CD25 and CD38 in CD3+/CD3+CD4+/CD3+CD8+T subset, as well as HLA-DR levels in CD3+/CD3+CD4+T subsets, between patients with G-/G+ bacterial sepsis. The gene discussed is CD4; the disease is bacterial infectious disease with sepsis.